The lectures on Clinical Translation of Stem Cells emphasize the scientific, clinical, regulatory, ethical, and social issues that should be addressed so that basic stem cell research is responsibly translated into appropriate clinical applications for treating patients. These lectures by multidisciplinary group of stem cell experts comprise researchers, clinicians, ethicists, and regulatory specialists who offer recommendations founded on general principles for scientific, clinical, and ethical conduct that should be followed by all translational stem cell researchers, clinician-scientists, and regulators in this fascinating field described as the “next evolution of medical treatments.".
The course comprises clinical translational research involving products from human embryonic or other pluripotent stem cells, novel applications of fetal or somatic (adult) stem cells, and hematopoietic or other stem cells used for applications outside established standards of care. The major areas of translational stem cell research covered are: (a) cell processing and manufacture; (b) preclinical studies; and (c) clinical research.
Dalton - Pluripotent Stem Cells and Cell Therapy
|The purpose of this unit is to understand differentiation. Also, to understand the basic cell therapy pathway and treatment in focus areas.|
Borlongan - Clinical Application of Mesenchymal Stem Cells
|This unit gives an Overview of cell therapy and human disorders with a Brief history of stem cell therapy. Preclinical studies of adult cell transplants and the Missing link between lab and clinical trials will also be discussed. This unit describes the Translational approach.|
Ratajczak - Understanding the Concepts of Stem Cell Trafficking and Mobilization
|This unit covers Stem Cell trafficking and factors that regulate it.|
Byrnes - Immunology of Stem Cell Transplantation
|This unit covers the following: the History and Overview, Graft Sources. HLA System, HLA System wrt Graft Sources, Graft-Host Interaction, Roles for Mesenchymal Cells, and The Future and iPS|
Maharaj - Adult Stem Cells - Current Clinical Treatments
|The purpose of this unit is to introduce Adult Stem Cells and their importance in Treatment.|
McNiece - Development of New Cellular Therapies
|The unit discusses pathology and current cellular treatments.|
McNiece - Stem Cells and Regenerative Medicine
|The purpose of this unit is to understand stem cell origin. It also covers Hematopoietic Stem Cells along with Regenerative Medicine.|
Ratajczak - Stem Cells - Regeneration of Tissues
|This unit discusses Aging and Regeneration. This unit also describes clinical Applications of Stem Cells.|
Estrada - Cell Therapy Applications
The purpose of this unit is to understand the acceptability of Stem Cell Therapies, to understand efficacy of treatment in certain diseases and to be able to answer the question "Where does cell therapy stand now?"
Estrada - Cell Therapy Applications Part 2
Maharaj - Stem Cells & Regenerative Medicine
|The purpose of this unit is to Understand what regenerative medicine is and Understand what adult stem cells are. This unit also coves which medical conditions may benefit from regenerative medicine, the sources of stem cells for regenerative medicine and the clinical applications in Diabetes.|
McNiece - Current Issues in Stem Cell-Based Therapies
|This unit discusses Regulatory and manufacturing Issues. This unit also covers Trial Design, Cell Dosing and the Delivery of Cellular Products.|
Maharaj - Stem Cells & Regenerative Medicine
The purpose of this unit is to understand what regenerative medicine is,understand what adult stem cells are, understand which medical conditions may benefit from regenerative medicine, understand the sources of stem cells for regenerative medicine and understand the clinical applications in Diabetes.
Maharaj - Stem Cell Research from a Patient Perspective
The purpose of this unit is to understand the ability of mechanical stimulation to enhance the regenerative potential of endogenous muscle stem cells.
Quyyumi - The Biology of Endothelial Progenitor Cells
The purpose of this unit is to be able to answer the question "What are endothelial cells?", to be able to understand the Function of EPCs, Identification of EPCs. EPCs and cardiovascular diseases
Chen - Clinical Applications of Mesenchymal Stem Cells
The purpose of this unit is to understand Clinical Perspectives of MSCs including: In Vitro Engineering of Human Ear-Shaped Cartilage, Utility of Periodontal Ligament Progenitors for Treating Periodontitis, MSC Transplantation for Trating Systemic Lupus Erythematosus Patients, and Rescuing Aged MSCs by Exposure to Young ECM.
Dalton - Progress in Induced Pluripotent Stem Cell Therapies
|The purpose of this unit is to understand stem cells, cell identity and differentiation. This unit also cover Progress in Cardiovascular Disease Treatment, Progress in Neurodegenerative Disease and Progress in Type 1 Diabetes. |
Chen - Principles of Mesenchymal Stem Cell-Based Therapy
Ambrosio - Stem Cells in Regenerative Rehabilitative Therapies