Course Summary
MusculoskeletalMusculoskeletal disease is prevalent in society and with an ageing population, the incidence and impact on public health are set to rise. Severe long-term pain and mobility restriction impair the welfare and quality of life of patients with musculoskeletal disease. Current treatments are often restricted to the management of symptoms or temporary replacement with inert materials, rather than targeting prevention and cure. There is an urgent need for alternative biological approaches to musculoskeletal disease therapy. The rapid emergence of stem cell technologies, primarily using ‘mesenchymal stem cells’ (MSCs), has resulted in a number of pre-clinical and clinical studies in an effort to provide more effective treatment options. Challenges exist in bench-to-bedside translation, but they are not insurmountable.
What's Included
Ratajczak - Understanding the Concept of Stem Cell Niches
| The unit Describes the microenvironment in which stem cells reside and the factors that regulate their characteristics within the niche. |
Cooper - Applications of Stem Cells for Bone Diseases
| Th purpose of this unit is to Identify bone disease amenable to stem cell therapy, Identify stem cell options for treatment and to Define regeneration vs repair of bone tissue in stem cell therapy. |
Bemden - Clinical Trials of Cell-Based Approaches for Orthopedic Applications
| This unit is a review of clinical trial outcomes using ACI, Stem Cell, Cytokines, PRP. |
Biscup - Regenerative Therapy for Back and Degenerative Spinal Disorders
| The unit discusses the innovative procedures for Spinal disorders that reduces cost, invasiveness, and age limits, while allowing for faster recovery. |
Biscup - Spinal Anatomy and Pathology
| This unit gives insight on the anatomy and pathology of Spinal Problems which affect 80% of the population and is the #1 Cause of Disability and WC Claims. |
Purita - The Use of Supplements in Platelet Rich Plasma Injections and Stem Cell Treatments
| This unit discusses the ways in which the body can be prepared for Platelet Rich Plasma and Stem Cell Injections. It also uncovers ways in which we can allow endogenous stem cells to be part of stem cell treatment. |
Chen - Clinical Applications of Mesenchymal Stem Cells
| This unit covers Clinical Perspectives of MSCs including: In Vitro Engineering of Human Ear-Shaped Cartilage, Utility of Periodontal Ligament Progenitors for Treating Periodontitis, MSC Transplantation for Trating Systemic Lupus Erythematosus Patients, and Rescuing Aged MSCs by Exposure to Young ECM. |
Cralle - Rehabilitation for Improved Stem Cell Function using Hyperbaric Therapies
| The purpose of this unit is to explore the effects of Hyperbaric Oxygen This unit discusses therapies on the Immune system, tissue oxygenation, and free radical damage and how this therapy is being applied. |
Ambrosio - Skeletal Muscle Stem Cell-Mediated Regeneration
| This unit provides an overview of skeletal muscle regenerative cascade. |
Ambrosio - Stem Cells in Regenerative Rehabilitative Therapies
| This unit cover the ability of mechanical stimulation to enhance the regenerative potential of endogenous muscle stem cells. |
Lee - Mesenchymal Stem Cells for Inflammatory Diseases
| This unit describes how mesenchymal stem cells are aiding in inflamation. |
Lee - Therapeutic Applications of Mesenchymal Stem Cells
| This unit explains mesenchymal stem cells and how mesenchymal stem cells repair injured tissue. This unit also uncovers the current status of clinical trials with mesenchymal stem cells. |
