Course Details

Course Summary

Stem Cell and Cancer Immunotherapy

Hematopoietic stem cells (HSCs)  are derived from mesoderm and give rise to all the other blood cells. They are usually extracted from bone marrow, peripheral blood, or umbilical cord blood. Hematopoietic stem cell transplantation involves the intravenous infusion of autologous or allogeneic stem cells to reestablish hematopoietic function in patients whose bone marrow or immune system is damaged or defective. Hematopoietic stem cell transplantations are often performed to eliminate a bone marrow infiltrative process, such as leukemia, or to correct congenital immunodeficiency disorders. Hematopoietic stem cell transplantation allows patients with cancer to receive higher doses of chemotherapy than the bone marrow can usually tolerate; bone marrow function is then salvaged by replacing the marrow with previously harvested stem cells.

Hematopoietic stem cells (HSCs) provide an attractive target for immunotherapy of cancer and leukemia by the introduction of genes encoding T-cell receptors (TCRs) or chimeric antigen receptors (CARs) directed against tumor-associated antigens. HSCs engraft for long-term blood cell production and could provide a continuous source of targeted anti-cancer effector cells to sustain remissions. T cells produced de novo from HSCs may continuously replenish anti-tumor T cells that have become anergic or exhausted from ex vivo expansion or exposure to the intratumoral microenvironment. In addition, transgenic T cells produced in vivo undergo allelic exclusion, preventing co-expression of an endogenous TCR that could mis-pair with the introduced TCR chains and blunt activity or even cause off-target reactivity. CAR-engineered HSCs may produce myeloid and natural killer cells in addition to T cells expressing the CAR, providing broader anti-tumor activity that arises quickly after transplant and does not solely require de novo thymopoiesis. Use of TCR- or CAR-engineered HSCs would likely require cytoreductive conditioning to achieve long-term engraftment, and this approach may be used in clinical settings where autologous HSC transplant is being performed to add a graft-versus-tumor effect. Results of experimental and preclinical studies performed to are presented in this course.


What's Included

Byrnes - Immunology of Stem Cell Transplantation

This unit will cover graft sources, as well as HLA systems, HLA system wrt Graft Sources, and Graft-Host Interaction. The unit will also introduce roles for mesenchymal Cells.

Byrnes - Bone Marrow Stem Cell Transplantation

This unit will review the history and currently accepted applications of autologous stem cell transplant, as well as survey some of the applications of autologous stem cell transplant currently being explored in ongoing clinical trials. The unit will also examine some of the recent break-thru findings in preclinical studies that are likely to impact future clinical applications.

Maharaj - Stem Cells & Regenerative Medicine

The purpose of this unit is to understand what regenerative medicine is, understand what adult stem cells are, as well understand which medical conditions may benefit from regenerative medicine. The unit will also cover the sources of stem cells for regenerative medicine and the clinical applications in Diabetes.

Cui - Immunology of Stem Cell Therapy

This unit will cover the source of hematopoietic stem cells, storage and manipulation of stem cells, as well as immunological reactions of graft vs host. The unit will also portray the present and future of xenotransplantation

Maharaj - Understanding the Basics of Cellular & Molecular Organization

This unit will cover the types and sources of Stem Cells in peripheral blood, as well as their specific cell surface markers and factors that change their abundance in peripheral blood. The unit will also cover the role of peripheral blood derived Stem Cells in normal and pathological processes.

Porada - Hematopoietic Stem Cells

This unit will introduce the concept of Hematopoietic Stem Cell (HSC), HSC phenotype, and the potential of HSC. The unit will also cover  long-term and short-term engrafting HSC, as well as hematopoietic stem cell niches and mobilization of HSC and the use of Cord blood derived HSC.

Lee - Mesenchymal Stem Cells for Cancer Treatment

This unit will cover the microenvironment of Cancer cell, mesenchymal Stem Cells treatment, and Clinical Studies.

Maharaj - Hematopoietic Stem Cell Transplant Tx Cancer in the Genomic Era

The purpose of this unit is to understand hematopoietic Stem Cell transplant, as well as treatment and success for Cancer and Cancer prevention. 

Cui - Immunology of Stem Cell Therapy

This unit will introduce the source of hematopoietic stem cells, as well as storage and manipulation of stem cells. The unit will also cover immunological reactions of graft vs host and immunological reactions of host vs graft.

Cui - Natural Cancer Resistance in Mice and in Humans - Basis for a Novel Cancer Therapy

This unit will cover cancer resistance.

Maharaj - Hematopoietic Stem Cell Transplantation

The purpose of this unit is to become familiar with hematopoietic stem cell transplantation: Allogeneic, Syngeneic, Autologous. The unit will also cover indications for stem cell transplant and complications of stem cell transplant.

Lathia - Basics of Cancer Development

The purpose of this unit is to understand the role of environmental factors on the initiation of cancer and understand the role of genetic mutations in the development of cancer. The unit will also cover the major signaling pathways involved in tumorigenesis.

Lathia - Current Cancer Stem Cell Research - Moving to a Cure

The purpose of this unit is to understand the cancer stem cell hypothesis and become familiar with how cancer stem cells contribute to a tumor. The unit will also cover cancer stem cell specific therapies.

Lathia - Laboratory Methods Commonly Used in Cancer Research

The purpose of this unit is to become familiar with essential cancer research techniques and understand how basic techniques allow for the evaluation of cancer associated behaviors. The unit will also cover how new technology is contributing to cancer research.

Maharaj - Hematopoietic Cell Transplantation 2

This unit will cover indications for transplantation, as well as the phases of transplantation and symptoms.

Enrollment Cost

Price: 
$1,500.00 (tax incl.)

Course Specifics


Course Title

Stem Cell and Cancer Immunotherapy

Total Lectures

15

Total Units

14

Total Length

00:00:00