Course Summary
Translational Stem Cell Research 1Stem cells for regenerative medicine is described as the "next evolution of medical treatments." An understanding of the basics of stem cells is critical to entry into this new paradigm in medicine. Pioneering and passionate educators take you inside their astonishing world and show you how they work to unravel the mysteries of this fascinating field. The advanced interactive curriculum teaches physicians and healthcare providers how stem cell protocols are being developed as a basis for future treatments in stem cells and regenerative medicine to help their patients.
What's Included
Dalton - Pluripotent Stem Cells and Cell Therapy
| The purpose of this unit is to understand differentiation, the process by which a more specialized cell is formed from a stem cell. Understand the basic Cell Therapy Pathway and treatment in focus areas. |
Dalton - Reprogramming, Induced Pluripotency and Trans-Differentiation
| The purpose of this unit is to understand Cell Identity and Differentiation. Understand reprogramming. Understand iPSC and downfalls. |
Maharaj - Understanding the Principles and Properties of Stem Cells
| The purpose of this unit is to explore the origin of stem cell studies and their applications since. Understand properties of stem cells and current and future problems in their use. |
Ratajczak - Understanding the Concept of Stem Cell Niches
| This unit describes the microenvironment in which stem cells reside and the factors that regulate their characteristics within the niche. |
Ratajczak - Embryonic Vs. Adult Stem Cells in Therapy
| The purpose of this unit is to explain the hierarchy of Stem Cells. The unit will also introduce sources for Pluripotent Stem Cells. |
Cui - Immunology of Stem Cell Therapy
| This unit will explain the source of hematopoietic stem cells. It will also cover storage and manipulation of stem cells, Immunological reactions of graft vs host and Immunological reactions of host vs graft. Lastly, it will portray the present and future of xenotransplantation |
Cooper - Cell Signaling
| The purpose of this unit is to understand the basics of how signaling pathways are organized in the cell and how ligands/growth factors binding to receptors can elicit a response in the nucleus that involves activation of a gene. This unit will help understand the differences between different cellular receptors and recognize the major signaling pathways involved in stem cell maintenance and differentiation. |
Cooper - Stem Cells - Growth Factors and Differentiation
| The purpose of this unit is to understand that there are 5 major signaling pathways that maintain pluripotency and initiate differentiation. Also, to understand that pluripotency is noted by hESE markers that are regulated by the pathways Erk1/2, via FGF, ?- catenin, via Wnt; Smad2/3 via TGF-?. Notch is involved in differentiation. Hedgehog is involved differentiation. |
Andrews - Telomerase in Stem Cells
| This the purpose of this unit is to understand Telomeres and Telomere Shortening. Also understand the pathology of Telomere shortening. Keeping Telomeres Long. |
Maharaj - Understanding the Basics of Cellular & Molecular Organization
| This unit introduces the types and sources of stem cells in peripheral blood, their specific cell surface markers and factors that change their abundance in peripheral blood, and the role of peripheral blood derived stem cells in normal and pathological processes. |
Porada - Hematopoietic Stem Cells
| This unit covers the concept of Hematopoietic Stem Cell (HSC) and HSC phenotype. The unit examines testing of the potential of HSC, long-term and short-term engrafting HSC, Hematopoietic stem cell niches, and Mobilization of HSC and the use of Cord blood derived HSC. |
Porada - Intestinal Stem Cells and Intestinal Repair
| The purpose of this unit is to understand Intestinal Anatomy and Intestinal Stem Cells; as well as Intestinal Pathology and Treatment. |
